| 1 | Community Fdn of Greater des Moines Des Moines | $319.8M | $160.8M | $918.7M |
| 2 | Community Foundation of Greater Dubuque Dubuque | $89.9M | $29.1M | $165.4M |
| 3 | Quad Cities Community Foundation Bettendorf | $83.2M | $25.3M | $209.7M |
| 4 | Community Foundation for Western Iowa Council Blfs | $80.2M | $40.7M | $83.3M |
| 5 | Better Health Foundation Davenport | $58.6M | $0 | $45.7M |
| 6 | Telligen Community Initiative West des Moines | $32.3M | $0 | $39.0M |
| 7 | Boazs Harvest-zachary Foundatoin Cedar Falls | $28.5M | $0 | $621K |
| 8 | Community Foundation of Northeast Iowa Cedar Falls | $27.4M | $14.5M | $171.0M |
| 9 | The Wallace Research Foundation Cedar Rapids | $27.2M | $0 | $75.4M |
| 10 | The Stanley Foundation Muscatine | $26.4M | $0 | $134.5M |
| 11 | Sehgal Foundation Des Moines | $26.2M | $0 | $57.1M |
| 12 | Greater Cedar Rapids Community Foundation Cedar Rapids | $25.6M | $20.2M | $229.3M |
| 13 | Community Foundation of Johnson Coralville | $24.5M | $9.4M | $72.8M |
| 14 | Butler Family Foundation Dubuque | $23.4M | $0 | $38.0M |
| 15 | Community Foundation of Greater Muscatine Muscatine | $21.4M | $18.2M | $93.4M |
| 16 | Eric Schwartz Fam Foundation Fairfield | $20.1M | $0 | $32.8M |
| 17 | Hills Bank Donor Advised Gift Fund North Liberty | $19.8M | $11.0M | $25.1M |
| 18 | Charles E Lakin Foundation INC Council Blfs | $19.0M | $0 | $134.9M |
| 19 | World Food Prize Foundation Urbandale | $18.7M | $0 | $58.4M |
| 20 | Max and Helen Guernsey Charitable Foundation Cedar Falls | $16.9M | $0 | $49.9M |
| 21 | Golf Charitable Foundation of Greater des Moines Des Moines | $16.4M | $16.4M | $2.8M |
| 22 | Eric and Kelly Schwartz Charitable Trust Fairfield | $13.7M | $13.7M | $332.5M |
| 23 | Lauridsen Family Foundation Ankeny | $13.7M | $0 | $20.8M |
| 24 | Siouxland Community Foundation Sioux City | $12.7M | $6.2M | $50.8M |
| 25 | Bookey Family Foundation Des Moines | $12.6M | $0 | $7.2M |
| 26 | Russell Reineke Foundation Carroll | $11.9M | $0 | $9.0M |
| 27 | Keokuk Area Community Foundation Keokuk | $11.4M | $11.4M | $32.9M |
| 28 | Goldstein Family Foundation Bettendorf | $9.8M | $0 | $11.3M |
| 29 | Roland & Ruby Holden Foundation Mount Vernon | $9.5M | $0 | $25.7M |
| 30 | Believers Stewardship Services INC Dubuque | $9.0M | $4.8M | $23.4M |
| 31 | Deb & Bob Pulver Foundation Wdm | $8.5M | $0 | $19.2M |
| 32 | Midamerican Energy Foundation Des Moines | $8.1M | $0 | $40.2M |
| 33 | Gerdin Charitable Foundation North Liberty | $7.6M | $0 | $67.1M |
| 34 | Van G Miller Family Charitable Foundation Waterloo | $7.4M | $0 | $36.1M |
| 35 | United Way of East Central Iowa Cedar Rapids | $7.0M | $6.3M | $19.2M |
| 36 | Greater Poweshiek Community Foundation Grinnell | $6.8M | $6.8M | $18.5M |
| 37 | Morgan E Cline Perpetual Charitable Foundation Centerville | $6.8M | $0 | $15.0M |
| 38 | Carleen and Eugene Grandon Charitable Foundation Cedar Rapids | $6.8M | $0 | $31.4M |
| 39 | United Way Quad Cities Bettendorf | $6.6M | $6.6M | $13.1M |
| 40 | Worth County Development Authority Northwood | $6.6M | $6.6M | $7.5M |
| 41 | Athene Charitable Foundation West des Moines | $6.5M | $0 | $3.9M |
| 42 | Donald F & Charlene K Lamberti Foundation Ankeny | $6.5M | $0 | $9.0M |
| 43 | Dean J King Family Foundation Logan | $6.1M | $0 | $33.8M |
| 44 | Butler Childrens Garden Foundation INC Dubuque | $6.1M | $0 | $9.0M |
| 45 | Gilchrist Foundation Sioux City | $6.0M | $0 | $33.4M |
| 46 | Community Foundation of des Moines County Burlington | $5.7M | $1.9M | $5.2M |
| 47 | Dewolf Family Foundation Cedar Rapids | $5.4M | $0 | $6.8M |
| 48 | Washington County Riverboat Foundation Washington | $5.1M | $5.1M | $4.0M |
| 49 | Adams Family Foundation of Nora Springs Iowa Nora Springs | $5.1M | $0 | $22.7M |
| 50 | Chrysalis Foundation Wdm | $4.8M | $575K | $11.4M |