| 1 | Raymond James Charitable Endowment Fund St. Petersburg | $3.2B | $955.1M | $2.4B |
| 2 | Dechomai Asset Trust Jacksonville | $716.6M | $459.6M | $1.5B |
| 3 | Community Foundation of Tampa Bay INC Tampa | $582.3M | $203.6M | $879.2M |
| 4 | Dechomai Foundation INC Jacksonville | $524.9M | $494.6M | $169.5M |
| 5 | The Frederick a Deluca Foundation INC Pompano Beach | $501.1M | $0 | $719.7M |
| 6 | Betty Wold Johnson Foundation West Palm Bch | $402.1M | $0 | $874.8M |
| 7 | The Miami Foundation INC Miami | $344.6M | $138.6M | $565.2M |
| 8 | Carl Angus Desantis Foundation INC Delray Beach | $323.7M | $0 | $385.8M |
| 9 | Truist Foundation INC Orlando | $290.9M | $0 | $547.9M |
| 10 | Elisabeth C Deluca Foundation INC Pompano Beach | $264.2M | $0 | $599.7M |
| 11 | Jim Moran Foundation INC Deerfield Bch | $246.5M | $0 | $283.3M |
| 12 | Blue Cross and Blue Shield of Florida Foundation INC Jacksonville | $241.7M | $0 | $450.3M |
| 13 | Greater Miami Jewish Federation Miami | $229.1M | $102.3M | $487.2M |
| 14 | Community Foundation of Sarasota County INC Sarasota | $212.5M | $87.0M | $518.5M |
| 15 | Givewell Community Foundation INC Lakeland | $196.2M | $63.7M | $669.9M |
| 16 | Gulf Coast Community Foundation INC Venice | $170.0M | $54.4M | $482.8M |
| 17 | The Invisible Hand Foundation Miami | $159.1M | $0 | $609.9M |
| 18 | Community Foundation for Palm Beach & Martin Counties INC West Palm Bch | $139.1M | $36.1M | $269.8M |
| 19 | The Community Foundation for Northeast Florida INC Jacksonville | $134.0M | $112.3M | $708.7M |
| 20 | Arison Arts Foundation Coral Gables | $129.6M | $0 | $381.2M |
| 21 | Barbara Newington Foundation Palm Beach | $128.7M | $0 | $218.0M |
| 22 | Albert L Ueltschi Foundation Vero Beach | $128.1M | $0 | $267.2M |
| 23 | Eunice Joyce Gardiner Charitable Foundation Palm Beach | $123.9M | $0 | $139.0M |
| 24 | Walker Family Foundation West Palm Bch | $110.0M | $0 | $6.1M |
| 25 | Mightycause Charitable Foundation Marianna | $105.9M | $105.9M | $6.6M |
| 26 | United Way Miami INC Miami | $97.7M | $71.7M | $157.2M |
| 27 | Kovner Foundation Jupiter | $94.7M | $0 | $335.3M |
| 28 | Jupiter Medical Center Foundation INC Jupiter | $93.8M | $61.6M | $182.4M |
| 29 | Tim Tebow Foundation INC Jacksonville | $91.0M | $43.1M | $54.9M |
| 30 | Paul J Diamare Foundation Homestead | $87.9M | $0 | $106.9M |
| 31 | Micky and Madeleine Arison Family Foundation Coral Gables | $80.9M | $0 | $221.5M |
| 32 | United Jewish Community of Broward County INC Davie | $80.4M | $24.9M | $191.4M |
| 33 | Jbj Foundation INC Coral Gables | $77.7M | $0 | $219.6M |
| 34 | Laura & Isaac Perlmutter Foundation INC Lake Worth | $76.5M | $0 | $70.8M |
| 35 | The Patterson Foundation Sarasota | $75.7M | $0 | $303.9M |
| 36 | Community Foundation of Broward INC Fort Lauderdale | $73.4M | $35.8M | $284.8M |
| 37 | Ormjmp Foundation Boca Raton | $72.0M | $0 | $70.7M |
| 38 | Bravo Family Charitable Foundation Miami | $70.9M | $0 | $110.5M |
| 39 | Charles and Margery Barancik Foundation Sarasota | $66.3M | $0 | $577.8M |
| 40 | Jewish Federation of Palm Beach County INC West Palm Bch | $65.4M | $49.4M | $202.9M |
| 41 | Taft Foundation Fort Lauderdale | $63.7M | $0 | $240.0M |
| 42 | Booth Foundation Stuart | $63.4M | $0 | $88.8M |
| 43 | Deitch Family Charitable Support Trust Miami Beach | $62.6M | $52.6M | $77.5M |
| 44 | Naples Children and Education Naples | $61.5M | $40.1M | $105.6M |
| 45 | Miami Heart Research Institute INC Miami | $60.7M | $11.2M | $72.5M |
| 46 | Zhao-chen Family Foundation INC Miami | $59.8M | $0 | $86.3M |
| 47 | Harry T Mangurian Jr Foundation INC Ft Lauderdale | $56.2M | $0 | $69.7M |
| 48 | Community Foundation of North Florida INC Tallahassee | $56.0M | $7.5M | $111.7M |
| 49 | Volo Foundation Palm Bch Gdns | $53.2M | $0 | $125.9M |
| 50 | Pentecost Foundation Bradenton | $52.6M | $0 | $62.9M |