| 1 | Riverside Research Institute Fairfax | $189.3M | $189.3M | $171.5M |
| 2 | Commonwealth Foundation for Cancer Research Foundation Richmond | $101.2M | $25.0M | $50.9M |
| 3 | Conquer Cancer Fdn of the American Society of Clinical Oncology Alexandria | $44.2M | $41.4M | $120.7M |
| 4 | Medical Device Innovation Consortium Arlington | $28.2M | $28.2M | $11.8M |
| 5 | American Institute for Cancer Research Arlington | $13.5M | $10.7M | $17.9M |
| 6 | Kochhar Cancer Research Foundation Portsmouth | $9.6M | $6.1M | $9.6M |
| 7 | Prevent Cancer Foundation Alexandria | $9.5M | $8.1M | $22.0M |
| 8 | Asts Foundation Arlington | $8.6M | $1.8M | $25.1M |
| 9 | Society of Interventional Radiology Foundation Fairfax | $7.2M | $2.3M | $8.0M |
| 10 | Hae International Fairfax | $6.6M | $6.6M | $7.1M |
| 11 | Healthcare Regulatory Research Institute Alexandria | $6.2M | $6.2M | $34.7M |
| 12 | Richmond Institute for Veterans Research Richmond | $5.4M | $5.4M | $16.0M |
| 13 | Amga Foundation INC Alexandria | $4.5M | $4.5M | $3.9M |
| 14 | Lysosomal and Rare Disorders Research and Treatment Center INC Fairfax | $4.4M | $4.4M | $2.4M |
| 15 | National Pku Alliance INC Roanoke | $4.3M | $2.6M | $5.3M |
| 16 | Virginia Commonwealth University Intellectual Property Foundation Richmond | $3.9M | $3.9M | $6.3M |
| 17 | Spinal Research Foundation Reston | $3.1M | $0 | $2.8M |
| 18 | Pediatric Endocrine Society McLean | $3.1M | $2.6M | $8.5M |
| 19 | Aats Foundation Fairfax | $2.9M | $2.8M | $13.0M |
| 20 | Organization for Autism Research INC Arlington | $2.7M | $2.3M | $3.9M |
| 21 | IVI Foundation INC Alexandria | $2.3M | $2.3M | $854K |
| 22 | International Society for Cerebral Blood Flow and Metabolism INC Alexandria | $2.3M | $1.1M | $9.4M |
| 23 | Orthopaedic Research of Virginia Richmond | $2.2M | $258K | $834K |
| 24 | Adams Valve Foundation Reston | $2.1M | $2.1M | $2.1M |
| 25 | Patients Rising INC Reston | $2.1M | $2.1M | $1.1M |
| 26 | American Skin Association INC Charlottesvle | $1.9M | $1.7M | $3.0M |
| 27 | National Alliance Against Disparities in Patient Health Woodbridge | $1.9M | $1.9M | $448K |
| 28 | International Liver Transplantation Society Fredericksbrg | $1.7M | $1.7M | $4.7M |
| 29 | Piedmont Orthopedic Foundation Lynchburg | $1.4M | $895K | $3.0M |
| 30 | Foundation to Eradicate Duchenne INC Alexandria | $1.2M | $1.1M | $1.3M |
| 31 | Sapien Labs Arlington | $1.2M | $0 | $413K |
| 32 | Society for Developmental and Behavioral Pediatrics McLean | $1.0M | $966K | $1.5M |
| 33 | Mindspec INC McLean | $804K | $804K | $1.1M |
| 34 | Emerson Health Foundation Woodbridge | $766K | $0 | $500K |
| 35 | Decentralization Research Center Arlington | $758K | $758K | $554K |
| 36 | Neuro Developmental Treatment Association INC Alexandria | $730K | $730K | $402K |
| 37 | Pku Hope Foundation Leesburg | $704K | $704K | $1.1M |
| 38 | Uva Community Health INC Manassas | $648K | $648K | $12.7M |
| 39 | Council on Medical Student Education in Pediatrics McLean | $579K | $566K | $339K |
| 40 | Buffalo Initiative INC Mc Lean | $500K | $500K | $494K |
| 41 | Disabilty Rights and Resource Center INC Rocky Mount | $492K | $492K | $178K |
| 42 | American Cochlear Implant Alliance Foundation McLean | $483K | $483K | $2.6M |
| 43 | Friends of Faces Reston | $480K | $480K | $13.9M |
| 44 | Rilite Foundation Charlottesvle | $476K | $476K | $11K |
| 45 | Will Hardy Foundation Henrico | $384K | $290K | $288K |
| 46 | Riverside Healthcare Association INC Newport News | $360K | $360K | $463K |
| 47 | Hudson Institute of Mineralogy Keswick | $336K | $317K | $1.7M |
| 48 | Zhao & Xiang Jiai Medical Foundation INC Fairfax | $311K | $311K | $520K |
| 49 | Nimml Institute INC Blacksburg | $232K | $232K | $10K |
| 50 | Virginia Cardiac Services Quality Initiative South Riding | $226K | $226K | $531K |