| 1 | Texas Biomedical Research Institute San Antonio | $103.3M | $75.2M | $366.6M |
| 2 | Baylor Research Institute Dallas | $84.9M | $84.9M | $171.6M |
| 3 | Texas Heart Institute Houston | $65.7M | $24.7M | $263.4M |
| 4 | Leducq Foundation for Cardiovascular Research Houston | $41.3M | $0 | $88.4M |
| 5 | Retina Research Foundation Permanent Endowment Fund Houston | $39.9M | $6.1M | $74.4M |
| 6 | Mary Crowley Medical Research Center Royse City | $20.6M | $20.6M | $24.3M |
| 7 | Kidney Cancer Association Dallas | $16.8M | $4.9M | $26.5M |
| 8 | Clayton Foundation for Research Houston | $15.9M | $14.9M | $144.4M |
| 9 | Hermann Eye Fund Houston | $15.7M | $3.3M | $28.2M |
| 10 | Metis Foundation San Antonio | $14.4M | $14.4M | $4.3M |
| 11 | Foundation for Angelman Syndrome Therapeutics Austin | $9.7M | $5.4M | $44.9M |
| 12 | Retina Foundation of the Southwest Dallas | $8.5M | $8.4M | $13.7M |
| 13 | Childrens Medical Center Research Institute at the University of Tex Dallas | $7.3M | $7.3M | $8.0M |
| 14 | Pediatric Epilepsy Research Foundation Dallas | $6.8M | $0 | $35.2M |
| 15 | Cll Global Research Foundation Houston | $6.6M | $3.1M | $11.6M |
| 16 | Foundation for Advancing Veterans Health Research INC San Antonio | $6.5M | $6.0M | $6.1M |
| 17 | Siut North America INC Houston | $5.9M | $5.9M | $1.5M |
| 18 | National Ovarian Cancer Coalition INC Dallas | $5.7M | $5.4M | $5.3M |
| 19 | The Gordon and Mary Cain Pediatric Neurology Research Foundation Bellaire | $5.4M | $2.3M | $35.8M |
| 20 | Texas Health Research & Education Institute Arlington | $4.9M | $4.9M | $298K |
| 21 | Dallas Va Research Corporation Dallas | $4.9M | $3.6M | $2.5M |
| 22 | L-cmd Research Foundation Houston | $4.3M | $355K | $2.0M |
| 23 | Osteosarcoma Institute Dallas | $4.2M | $4.2M | $6.3M |
| 24 | Rare Village Foundation McKinney | $3.5M | $3.5M | $2.0M |
| 25 | Childrens Cancer Fund of Dallas INC Dallas | $3.3M | $2.3M | $390K |
| 26 | Retina Research Foundation Houston | $3.2M | $3.2M | $4.8M |
| 27 | Hub Houston INC Houston | $2.7M | $2.5M | $2.7M |
| 28 | Project Mend San Antonio | $2.5M | $2.5M | $4.9M |
| 29 | Coalition for National Trauma Research San Antonio | $2.5M | $2.5M | $1.0M |
| 30 | Texas Oncology Foundation INC Dallas | $2.3M | $2.1M | $3.5M |
| 31 | American-european Congress of Ophthalmic Surgery Fort Worth | $2.2M | $2.2M | $2.1M |
| 32 | Wilderness Medical Society INC Austin | $2.2M | $2.2M | $2.9M |
| 33 | The Carmage and Martha Ann Walls Foundation Houston | $2.0M | $0 | $5.9M |
| 34 | Guadalupe Regional Medical Foundation Seguin | $1.9M | $1.9M | $4.6M |
| 35 | Victory Houston INC Houston | $1.9M | $1.9M | $993K |
| 36 | Texas Academy of Medicine Engineering Science and Technology Austin | $1.7M | $1.7M | $23.1M |
| 37 | Cancer Prevention Initiative INC Dallas | $1.7M | $1.7M | $2.2M |
| 38 | Shelby Lavine Family Foundation Addison | $1.6M | $1.6M | $4.6M |
| 39 | Central Texas Veterans Research Foundation Temple | $1.5M | $1.5M | $1.4M |
| 40 | Monoamine Oxidase Deficiency Foundation Galveston | $1.4M | $921K | $205K |
| 41 | Restless Legs Syndrome Foundation INC Austin | $1.4M | $1.1M | $1.1M |
| 42 | Alstrom Angels Corp. Lubbock | $1.3M | $1.2M | $3.5M |
| 43 | Columbus Healthcare System Columbus | $1.3M | $1.3M | $53.4M |
| 44 | Johnsie & Aubary Montgomeryinstitute of Med Edu & Research INC Houston | $1.2M | $1.2M | $163K |
| 45 | Society of Hematologic Oncology The Woodlands | $1.2M | $1.2M | $641K |
| 46 | Bionorthtexas Foundation Irving | $1.1M | $1.1M | $418K |
| 47 | Childrens Airway First Foundation Austin | $1.0M | $1.0M | $1.1M |
| 48 | Neurtex Brain Research Institute INC Dallas | $981K | $981K | $587K |
| 49 | National Neurotrauma Society INC Houston | $981K | $981K | $972K |
| 50 | Myocarditis Foundation Kingwood | $935K | $468K | $2.6M |