| 1 | The V Foundation Cary | $74.6M | $61.6M | $145.9M |
| 2 | American Thrombosis and Hemostasisnetwork INC Hickory | $18.8M | $16.0M | $5.2M |
| 3 | Chordoma Foundation Durham | $5.4M | $5.4M | $11.4M |
| 4 | Pediatric Brain Tumor Foundation of the United States INC Winston Salem | $5.0M | $5.0M | $3.3M |
| 5 | Regenmed Development Organization Winstonsalem | $4.1M | $4.1M | $7.8M |
| 6 | Rome Foundation Raleigh | $2.9M | $2.9M | $1.7M |
| 7 | Project Ds INC Morrisville | $2.9M | $2.9M | $7.3M |
| 8 | Renu Life Extended Goldsboro | $2.7M | $2.7M | $6.2M |
| 9 | Orthocarolina Research Institute INC Charlotte | $2.6M | $2.6M | $4.1M |
| 10 | Glioblastoma Foundation INC Durham | $2.3M | $2.1M | $3.7M |
| 11 | North Carolina Pediatric Society INC Raleigh | $1.8M | $1.8M | $2.5M |
| 12 | Rare Cancer Research Foundation Durham | $1.8M | $1.8M | $3.1M |
| 13 | Readdi INC Durham | $1.5M | $1.5M | $1.7M |
| 14 | No One Left Alone Charlotte | $1.2M | $1.2M | $2.0M |
| 15 | Reelin for Research INC Greensboro | $1.1M | $989K | $1.2M |
| 16 | Spirovation INC Chapel Hill | $1.1M | $1.1M | $156K |
| 17 | Neuroimmune North Carolina Raleigh | $963K | $963K | $563K |
| 18 | Society for Translational Oncology INC Durham | $946K | $477K | $1.5M |
| 19 | Charlesson Foundation Lewisville | $914K | $479K | $5.5M |
| 20 | Health Enhancement Research Organization INC Raleigh | $718K | $718K | $120K |
| 21 | Dhit Global Carrboro | $694K | $694K | $343K |
| 22 | Studies in Philology Incorporated Chapel Hill | $668K | $330K | $697K |
| 23 | Health Research Alliance INC Raleigh | $647K | $631K | $828K |
| 24 | A Cure in Sight Edenton | $643K | $476K | $115K |
| 25 | Paula Takacs Foundation for Sarcoma Research Charlotte | $625K | $625K | $1.1M |
| 26 | Friends for an Earlier Breast Cancer Test INC Greensboro | $527K | $527K | $305K |
| 27 | Parkinson Association of the Carolinas Charlotte | $482K | $482K | $2.1M |
| 28 | North Carolina Association for Biomedical Research Raleigh | $472K | $472K | $763K |
| 29 | Wplab INC Durham | $441K | $238K | $189K |
| 30 | Salisbury Foundation for Research & Education Salisbury | $440K | $440K | $2.5M |
| 31 | Cancer Genomics Consortium Fletcher | $437K | $437K | $556K |
| 32 | Pearl Psychedelic Institute Waynesville | $383K | $383K | $40K |
| 33 | International Cannabinoid Research Society Winston Salem | $364K | $364K | $652K |
| 34 | The North Carolina Rheumatology Association Wilmington | $358K | $358K | $481K |
| 35 | Carolina Ear Research Institute Raleigh | $331K | $331K | $177K |
| 36 | Confederacion Americana de Urologia Cau INC Winston Salem | $308K | $308K | $1.5M |
| 37 | She Rocks INC Greensboro | $287K | $287K | $75K |
| 38 | Bacterial Locomotion and Signal Transduction Chapel Hill | $276K | $276K | $21K |
| 39 | American Association of Extracellular Vesicles INC Cary | $269K | $269K | $243K |
| 40 | Columbus Children Foundation Chapel Hill | $268K | $268K | $1.1M |
| 41 | International Neurosurgery Education and Research Foundation Raleigh | $232K | $232K | $380K |
| 42 | Megs Smile Foundation INC Holly Springs | $216K | $216K | $494K |
| 43 | Cancer Biology Training Consortium Chapel Hill | $208K | $208K | $100K |
| 44 | Academy of Clinical Research and Study Chapel Hill | $190K | $190K | $154K |
| 45 | Triangle Global Health Consortium INC Rtp | $178K | $178K | $36K |
| 46 | Cpm Billfish Tournament Morehead City | $169K | $145K | $76K |
| 47 | Live Like Madison INC Laurinburg | $163K | $163K | $117K |
| 48 | Cancer Active INC Asheville | $145K | $135K | $6K |
| 49 | International Cancer Care & Research Excellence Foundation INC Durham | $143K | $143K | $141K |
| 50 | Ella Foard Foundation for Rett Syndrome Charlotte | $125K | $90K | $88K |