| 1 | Van Andel Research Institute Grand Rapids | $113.5M | $112.7M | $190.5M |
| 2 | Barbara Ann Karmanos Cancer Institute Detroit | $112.4M | $25.4M | $250.7M |
| 3 | Fraunhofer USA INC Plymouth | $24.2M | $24.2M | $19.5M |
| 4 | Center for Healthcare Research & Transformation Ann Arbor | $10.5M | $10.5M | $2.7M |
| 5 | Lahser Interspecies Research Foundation Davison | $9.1M | $0 | $7.2M |
| 6 | Saint Marys Foundation Grand Rapids | $6.3M | $6.2M | $32.4M |
| 7 | Innovative Lifestyles INC Clarkston | $5.9M | $5.0M | $1.1M |
| 8 | Sarc Ann Arbor | $3.7M | $2.8M | $3.9M |
| 9 | Porter Hills Home Health West Grand Rapids | $3.1M | $3.1M | $731K |
| 10 | Interrai Ann Arbor | $1.7M | $1.4M | $5.6M |
| 11 | African American Health Institute Grand Rapids | $1.7M | $1.7M | $1.8M |
| 12 | Insight Research Institute Flint | $1.1M | $1.1M | $348K |
| 13 | Amyloidosis Foundation Clarkston | $1.0M | $689K | $1.1M |
| 14 | Sky Foundation INC Birmingham | $755K | $596K | $726K |
| 15 | Foundation for Vision Research Grand Rapids | $692K | $691K | $1.2M |
| 16 | Tremor Research Group INC Sylvan Lake | $614K | $614K | $897K |
| 17 | American Society for Virology INC Ann Arbor | $574K | $574K | $2.9M |
| 18 | Sinai Medical Staff Foundation Bloomfield Hills | $470K | $0 | $4.9M |
| 19 | Mircore Ann Arbor | $447K | $447K | $188K |
| 20 | Mid Central Area Health Education Center Mt Pleasant | $387K | $387K | $335K |
| 21 | Festival of Trees Carleton | $293K | $107K | $163K |
| 22 | National Bone Marrow Transplant Link Commerce Twp | $290K | $290K | $232K |
| 23 | Alternating Hemiplegia of Childhood Foundation INC Southfield | $283K | $283K | $1.7M |
| 24 | Affiliated University Nephrologists Detroit | $267K | $63K | $457K |
| 25 | Society for Pediatric Radiology Research & Education Foundation Okemos | $264K | $264K | $4.1M |
| 26 | Peach Philanthropic Endowment Advancing Childrens Health INC Holland | $221K | $199K | $227K |
| 27 | Adld Center Troy | $216K | $216K | $533K |
| 28 | Karmanos Cancer Foundation Detroit | $187K | $187K | $911K |
| 29 | Orthopaedic Associates of Grand Rapids Research & Education Inst Grand Rapids | $175K | $0 | $30K |
| 30 | Defeat Msa Alliance Defeat Multiple System Atrophy Alliance St. Clr Shores | $172K | $172K | $285K |
| 31 | Hope 365 Madison Hts | $171K | $171K | $135K |
| 32 | Renegade Research Brighton | $160K | $160K | $26K |
| 33 | Pediatric Retinal Research Foundation Warren | $157K | $154K | $1.2M |
| 34 | Love Team Tessa Royal Oak | $151K | $139K | $20K |
| 35 | Nick Gilbert Neurofibromatosis Research Institute Detroit | $150K | $150K | $150K |
| 36 | Barrel Aged Charities Co Dewitt | $143K | $0 | $202K |
| 37 | Institute for Injury Research Bloomfld Hls | $136K | $136K | $722K |
| 38 | Five Points of Hope Milford | $124K | $124K | $42K |
| 39 | Ann Arbor Active Against Als Ann Arbor | $124K | $110K | $205K |
| 40 | Kids Without Cancer Detroit | $119K | $119K | $258K |
| 41 | Fox in the D Novi | $117K | $76K | $2K |
| 42 | Detroit International Research and Education Foundation Warren | $116K | $116K | $213K |
| 43 | More Than Four Foundation Traverse City | $110K | $110K | $84K |
| 44 | Optimal Medical Foundation INC Sault S Marie | $108K | $108K | $17K |
| 45 | International Fluency Association W Bloomfield | $90K | $90K | $31K |
| 46 | Association of Telugu Medical Graduates in USA Battle Creek | $82K | $82K | $20K |
| 47 | Tony Open Jackson | $69K | $69K | $34K |
| 48 | Surgical Outcomes Club INC Howell | $58K | $58K | $228K |
| 49 | Fod Family Support Group Okemos | $50K | $50K | $293K |
| 50 | Interface Health Foundation INC Birmingham | $50K | $50K | $68K |