| 1 | Water Missions International North Charleston | $51.5M | $41.1M | $22.0M |
| 2 | American Leprosy Missions INC Greenville | $13.8M | $11.3M | $16.2M |
| 3 | Oneworld Health Charleston | $9.0M | $8.4M | $7.5M |
| 4 | Set Free Alliance Greenville | $4.3M | $4.2M | $228K |
| 5 | Global Water Center North Charleston | $4.1M | $4.1M | $4.3M |
| 6 | Rysr INC Charleston | $2.5M | $2.5M | $3.3M |
| 7 | Rice Bowl INC Spartanburg | $2.2M | $1.4M | $1.3M |
| 8 | Junior Achievement of Greater South Carolina Columbia | $1.5M | $1.5M | $2.3M |
| 9 | Ibu Foundation Charleston | $1.4M | $913K | $187K |
| 10 | Next Generation Ministries Lexington | $898K | $848K | $1.0M |
| 11 | Disciples Village Lexington | $864K | $864K | $632K |
| 12 | Middle East Ministries Fairforest | $799K | $799K | $354K |
| 13 | Lespri Ministries Fort Mill | $768K | $768K | $372K |
| 14 | Go Love York | $589K | $578K | $194K |
| 15 | Refuge International INC Gilbert | $574K | $209K | $136K |
| 16 | Stronger Than Ever Fort Mill | $437K | $437K | $6.4M |
| 17 | Ukrainian Action Daniel Island | $425K | $425K | $148K |
| 18 | Come Go with US INC Myrtle Beach | $422K | $400K | $484K |
| 19 | Saluda Charitable Foundation INC West Columbia | $411K | $0 | $769K |
| 20 | The Vimm Fnd World Missions Dept Church of God Internatl Headqters Seneca | $401K | $393K | $407K |
| 21 | International Friendship Ministries Columbia | $376K | $376K | $112K |
| 22 | Masters Missions INC N Myrtle Bch | $336K | $336K | $106K |
| 23 | Future Generation International Missions INC Cowpens | $327K | $327K | $910K |
| 24 | Center for Global Strategies Ltd Greenville | $298K | $298K | $327K |
| 25 | Goodjustice Fountain Inn | $253K | $253K | $251K |
| 26 | Strong Missions INC Greenville | $252K | $252K | $11K |
| 27 | World Affairs Council of Hilton Head Hilton Head Island | $252K | $252K | $159K |
| 28 | Medical Missions INC Charleston | $251K | $251K | $201K |
| 29 | Pearl Foundation INC Boiling Spgs | $249K | $249K | $97K |
| 30 | Evanjafrica INC Ridgeville | $248K | $248K | $19K |
| 31 | Give Back to Humanity INC Bluffton | $246K | $246K | $48K |
| 32 | Hydromissions Lexington | $242K | $242K | $151K |
| 33 | Ukrainian Patriot INC Columbia | $235K | $235K | $34K |
| 34 | Hands of Hope North Augusta | $227K | $224K | $240K |
| 35 | Crosscampus International Spartanburg | $222K | $222K | $112K |
| 36 | Haiti Under God INC Columbia | $218K | $218K | $345K |
| 37 | Tranquilidad Foundation Aiken | $218K | $218K | $755K |
| 38 | Japan America Assn of Western Sc INC Greenville | $216K | $216K | $172K |
| 39 | Zion Evangelistic & Care Ministriesinc Sheldon | $211K | $211K | $49K |
| 40 | Libraries for Kids Intl Bluffton | $184K | $152K | $56K |
| 41 | Emmanuel International Mission Rock Hill | $173K | $173K | $40K |
| 42 | Sister Nivedita Foundation USA INC Elgin | $167K | $167K | $1 |
| 43 | Columbia World Affairs Council INC Columbia | $167K | $167K | $40K |
| 44 | Gods Little Ones INC Irmo | $158K | $158K | $5K |
| 45 | 516 Now INC Spartanburg | $156K | $156K | $34K |
| 46 | Hands of Kindness Childrens Ministry Greenville | $156K | $152K | $29K |
| 47 | Global Leadership International INC Rock Hill | $140K | $140K | $125K |
| 48 | Empathy into Action Easley | $134K | $134K | $21K |
| 49 | Team Lee Pickens | $123K | $123K | $40K |
| 50 | R2m Elgin | $122K | $122K | $55K |