| 1 | Palmetto Goodwill Charleston | $104.2M | $65.1M | $137.2M |
| 2 | Lutheran Homes of South Carolina INC Irmo | $94.6M | $94.6M | $124.5M |
| 3 | Presbyterian Communities of South Carolina Columbia | $82.8M | $82.8M | $171.6M |
| 4 | Bishop Gadsden Episcopal Retirement Community Charleston | $70.6M | $70.1M | $337.1M |
| 5 | Connie Maxwell Childrens Home Greenwood | $55.0M | $18.8M | $146.9M |
| 6 | Miracle Hill Ministries INC Greenville | $42.0M | $26.3M | $45.8M |
| 7 | Babcock Center INC West Columbia | $40.7M | $40.7M | $22.5M |
| 8 | South Carolina Youth Advocate Program INC Columbia | $31.3M | $26.9M | $64.3M |
| 9 | South Carolina Baptist Ministries for the Aging INC Columbia | $31.1M | $29.9M | $52.4M |
| 10 | Wateree Community Actions INC Columbia | $30.4M | $30.4M | $8.2M |
| 11 | YMCA of Greenville Greenville | $30.3M | $29.8M | $88.5M |
| 12 | Wesley Commons Greenwood | $29.9M | $28.1M | $70.8M |
| 13 | Upstate Senior Living INC Greenville | $26.7M | $26.5M | $136.0M |
| 14 | Upper Palmetto YMCA Rock Hill | $23.2M | $23.2M | $55.0M |
| 15 | Palmetto Dunes Property Owners Association Hilton Head | $22.9M | $11.7M | $50.2M |
| 16 | Childrens Trust Fund of South Carolina Columbia | $20.8M | $20.8M | $11.4M |
| 17 | John K Crosswell Home Pof Sumter | $20.1M | $0 | $47.0M |
| 18 | Project Hope Foundation INC Greenville | $19.6M | $19.2M | $17.1M |
| 19 | Thornwell Clinton | $18.4M | $13.8M | $67.7M |
| 20 | Ray & Vera Conniff Foundation Fort Mill | $18.2M | $0 | $18.9M |
| 21 | Hospice of Laurens County INC Clinton | $16.9M | $16.5M | $9.2M |
| 22 | Berkeley Citizens INC Moncks Corner | $16.6M | $16.6M | $16.6M |
| 23 | Epworth Childrens Home Columbia | $16.4M | $16.4M | $58.4M |
| 24 | United Methodist Manor of the Pee Dee Florence | $15.7M | $15.0M | $34.2M |
| 25 | Carolina Community Actions INC Rock Hill | $13.8M | $13.7M | $3.1M |
| 26 | Horry Country Disabilities and Special Needs Board Conway | $12.9M | $12.9M | $13.7M |
| 27 | Safe Harbor INC Greenville | $12.8M | $12.7M | $19.5M |
| 28 | Charleston County Human Services Commission Charleston | $11.6M | $11.6M | $6.5M |
| 29 | Senior Solutions Anderson | $11.1M | $11.1M | $18.7M |
| 30 | Young Mens Christian Association-columbia Lexington | $10.0M | $9.9M | $22.6M |
| 31 | Clarendon County Disabilities & Special Needs Board Manning | $9.9M | $9.9M | $9.2M |
| 32 | Marion-dillon County Board of Disabilities and Special Needs Marion | $9.1M | $9.0M | $6.8M |
| 33 | Piedmont Community Actions INC Spartanburg | $8.7M | $8.7M | $2.4M |
| 34 | Chester Lancaster Disabilities & Special Needs Board INC Lancaster | $8.6M | $8.6M | $4.3M |
| 35 | Trident Area Agency on Aging INC N Charleston | $7.6M | $7.6M | $873K |
| 36 | Fpcrc INC Columbia | $7.4M | $1.7M | $25.2M |
| 37 | YMCA of Coastal Carolina Myrtle Beach | $7.3M | $7.2M | $12.0M |
| 38 | Darlington County Community Action Agency Hartsville | $7.0M | $7.0M | $3.8M |
| 39 | Second Helpings Hilton Head | $6.7M | $6.7M | $1.2M |
| 40 | Young Mens Christian Association of Sumter S C Sumter | $6.1M | $4.6M | $7.9M |
| 41 | New Foundations Home for Children INC Anderson | $6.1M | $6.1M | $4.1M |
| 42 | Foothills Area YMCA Seneca | $6.0M | $6.0M | $21.9M |
| 43 | East Cooper Community Outreach Mt Pleasant | $5.7M | $5.3M | $9.5M |
| 44 | My Sisters House INC N Charleston | $5.6M | $2.8M | $4.3M |
| 45 | Bamberg County Disabilities & Special Needs Board-fiscal Agent Denmark | $5.4M | $5.4M | $6.9M |
| 46 | Catawba Area Agency on Aging Rock Hill | $5.4M | $5.4M | $770K |
| 47 | Young Mens Christian Assoc of Anderson South Carolina INC Anderson | $5.1M | $4.9M | $25.0M |
| 48 | Cooperative Ministry Columbia | $5.1M | $5.0M | $3.8M |
| 49 | Jamaica Relief Ministries INC Fair Play | $5.0M | $2.0M | $4.1M |
| 50 | House of Hope of the Pee Dee Florence | $4.6M | $4.6M | $7.0M |