| 1 | Bjc Health System Saint Louis | $11.8B | $11.3B | $8.0B |
| 2 | Bjc Health System St. Louis | $6.5B | $2.0B | $7.8B |
| 3 | Ssm Health Care St. Louis Saint Louis | $2.2B | $2.2B | $1.1B |
| 4 | Childrens Mercy Hospital Kansas City | $2.1B | $2.1B | $3.3B |
| 5 | Lester E Cox Medical Center Springfield | $2.0B | $1.8B | $2.1B |
| 6 | Mercy Hospitals East Communities Chesterfield | $1.9B | $1.9B | $916.1M |
| 7 | Sacred Heart Health System INC Saint Louis | $1.7B | $1.7B | $981.7M |
| 8 | St. Vincent Hospital & Health Care Saint Louis | $1.5B | $1.5B | $1.1B |
| 9 | Ssm Health Care Corporation Saint Louis | $1.4B | $1.4B | $7.0B |
| 10 | Mercy Hospital Springfield Springfield | $1.3B | $1.3B | $555.3M |
| 11 | Saint Thomas West Hospital Saint Louis | $1.3B | $1.3B | $815.7M |
| 12 | Ssm Health Care of Oklahoma INC Saint Louis | $1.1B | $1.1B | $453.7M |
| 13 | Truman Medical Center Incorporated Kansas City | $835.9M | $835.9M | $517.0M |
| 14 | Presence St. Marys Hospital Presence Central and Suburban Hospitals Net Saint Louis | $807.3M | $807.2M | $530.0M |
| 15 | Freeman Health System Joplin | $795.1M | $709.6M | $734.7M |
| 16 | Heartland Regional Medical Center Saint Joseph | $782.7M | $782.2M | $495.4M |
| 17 | The Foundation for Barnes-jewish Hospital Saint Louis | $776.2M | $106.3M | $927.6M |
| 18 | Ssm Health Care of Wisconsin INC Saint Louis | $770.4M | $770.2M | $499.4M |
| 19 | Ascension via Christi Hospitals Wichita INC Saint Louis | $759.3M | $759.1M | $380.0M |
| 20 | St. Lukes Episcopal-presbyterian Hospital Chesterfield | $737.2M | $664.6M | $859.5M |
| 21 | Saint Francis Medical Center Cpe Girardeau | $695.1M | $695.1M | $1.7B |
| 22 | St. Marys Health INC Dba Ascension Saint Louis | $689.6M | $689.6M | $394.1M |
| 23 | Mercy Hospital South Saint Louis | $664.0M | $661.3M | $515.8M |
| 24 | Columbia St. Marys Hospital Milwaukee INC Saint Louis | $662.7M | $662.4M | $501.6M |
| 25 | St. John Medical Center INC Saint Louis | $600.4M | $600.4M | $328.2M |
| 26 | Agnesian Healthcare INC Saint Louis | $584.7M | $584.4M | $743.4M |
| 27 | Mercy Clinic Springfield Communities Chesterfield | $562.9M | $562.9M | $39.8M |
| 28 | Ascension Health Saint Louis | $525.8M | $233.0M | $292.9M |
| 29 | Saint Thomas Rutherford Hospital Saint Louis | $513.4M | $512.9M | $446.3M |
| 30 | St. Agnes Healthcare INC Saint Louis | $494.2M | $494.2M | $404.0M |
| 31 | Alexian Brothers Medical Center Saint Louis | $482.5M | $482.0M | $332.5M |
| 32 | Ssm Cardinal Glennon Childrens Hospital Saint Louis | $442.1M | $441.3M | $602.9M |
| 33 | Ch Allied Services INC Columbia | $438.8M | $438.3M | $238.0M |
| 34 | Ascension Borgess Hospital Saint Louis | $405.0M | $402.3M | $219.8M |
| 35 | Ascension Se Wisconsin Hospital INC Saint Louis | $388.4M | $388.4M | $293.3M |
| 36 | St. Alexius Medical Center Saint Louis | $378.1M | $377.4M | $257.6M |
| 37 | Ascension Ne Wisconsin INC Saint Louis | $363.3M | $363.3M | $311.9M |
| 38 | Ssm Health Care Group Saint Louis | $351.9M | $351.9M | $175.8M |
| 39 | Coxhealth Springfield | $323.1M | $323.1M | $1.8B |
| 40 | Skaggs Community Hospital Association Branson | $320.8M | $299.9M | $355.2M |
| 41 | St. Louis Childrens Hospital Foundation Saint Louis | $320.1M | $159.1M | $631.7M |
| 42 | Saint Thomas Medical Partners Saint Louis | $310.0M | $310.0M | $115.3M |
| 43 | Mercy Hospital Joplin Joplin | $308.7M | $308.7M | $174.7M |
| 44 | Ascension All Saints Hospital INC Saint Louis | $308.2M | $308.2M | $282.8M |
| 45 | Hannibal Regional Healthcare System INC Hannibal | $302.9M | $301.9M | $199.3M |
| 46 | Ascension Providence Saint Louis | $301.9M | $301.7M | $200.9M |
| 47 | Ozarks Medical Center West Plains | $289.8M | $261.4M | $195.0M |
| 48 | Lake Regional Health System Osage Beach | $287.7M | $257.5M | $255.2M |
| 49 | Ssm Health Businesses Saint Louis | $274.0M | $273.9M | $284.6M |
| 50 | Good Samaritan Regional Health Center Saint Louis | $264.5M | $264.5M | $169.9M |