| 1 | American Heart Association INC Dallas | $1.0B | $972.8M | $1.9B |
| 2 | Susan G Komen Breast Cancer Foundation Dallas | $138.9M | $103.2M | $178.9M |
| 3 | Aids Arms INC Dallas | $125.0M | $124.9M | $47.8M |
| 4 | Travis Association for the Blind Austin | $86.5M | $40.1M | $88.9M |
| 5 | Federation of State Medical Boards of the United States INC Euless | $77.7M | $67.0M | $115.9M |
| 6 | South Texas Lighthouse for the Blind Corp Christi | $58.1M | $9.2M | $40.8M |
| 7 | Knights Templar Eye Foundation INC Flower Mound | $54.3M | $12.6M | $201.3M |
| 8 | Gulf Coast Center League City | $41.8M | $41.8M | $21.5M |
| 9 | Auditory Learning Foundation San Antonio | $39.3M | $16.7M | $181.3M |
| 10 | Houston Area Community Services INC Houston | $35.7M | $35.7M | $16.4M |
| 11 | Easter Seals of Greater Houston INC Houston | $31.9M | $29.9M | $11.6M |
| 12 | Vivent Health Texas INC Austin | $31.2M | $13.8M | $59.2M |
| 13 | Resource Center of Dallas INC Dallas | $27.4M | $21.9M | $34.6M |
| 14 | Alamo Area Resource Center INC San Antonio | $26.7M | $26.7M | $18.2M |
| 15 | Health Services of North Texas INC Denton | $23.0M | $23.0M | $11.4M |
| 16 | Texas Heart Medical Group Houston | $19.7M | $19.7M | $13.2M |
| 17 | Coastal Bend Wellness Foundation INC Corp Christi | $17.6M | $17.6M | $25.5M |
| 18 | Valley Aids Council Harlingen | $17.4M | $17.4M | $13.1M |
| 19 | Aids Foundation Houston INC Houston | $16.6M | $15.5M | $10.3M |
| 20 | San Antonio Aids Foundation San Antonio | $15.0M | $14.9M | $2.9M |
| 21 | Ut Southwestern Moncrief Cancer Center Fort Worth | $14.0M | $14.0M | $37.1M |
| 22 | Maryland University of Integrative Health INC Dallas | $12.8M | $4.9M | $1.1M |
| 23 | Ability Connection Texas Irving | $12.8M | $12.8M | $8.4M |
| 24 | St. Davids Foundation Community Fund Austin | $12.7M | $12.6M | $63.4M |
| 25 | Kelsey Research Foundation Houston | $9.7M | $3.6M | $10.5M |
| 26 | Knapp Medical Center Foundation INC Weslaco | $8.8M | $0 | $11.6M |
| 27 | Houston Lighthouse Foundation INC Houston | $8.3M | $1.9M | $46.0M |
| 28 | Isla Carroll Turner Friendship Tr Houston | $8.1M | $0 | $2.3M |
| 29 | 29 Acres INC Cross Roads | $7.9M | $7.7M | $17.8M |
| 30 | Beacon Lighthouse INC Wichita Falls | $7.0M | $7.0M | $2.9M |
| 31 | Aids Outreach Center INC Fort Worth | $6.3M | $6.3M | $1.6M |
| 32 | Center for Advanced Pathogen Threat and Response Simulation Austin | $6.1M | $3.5M | $1.8M |
| 33 | Mid Coast Medical Clinic El Campo | $6.1M | $6.1M | $0 |
| 34 | Heartgift Foundation Austin | $5.9M | $5.4M | $4.5M |
| 35 | Blue Bird Circle Houston | $5.8M | $3.2M | $17.0M |
| 36 | Lighthouse for the Blind of Houston Houston | $5.3M | $4.2M | $24.5M |
| 37 | American Respiratory Care Foundation Addison | $5.3M | $1.4M | $4.6M |
| 38 | Parkinson Voice Project INC Richardson | $5.0M | $3.6M | $22.2M |
| 39 | Cancer Care Services Fort Worth | $4.2M | $3.5M | $6.0M |
| 40 | Coalition for Barrier Free Living Houston | $3.7M | $3.7M | $2.5M |
| 41 | Halo House Foundation Houston | $3.7M | $3.5M | $18.8M |
| 42 | Panhandle Aids Support Organization INC Amarillo | $3.7M | $3.6M | $2.1M |
| 43 | International Society for Burn Injuries League City | $3.6M | $1.3M | $6.5M |
| 44 | Midland Childrens Rehabilitation Center INC Midland | $3.5M | $3.2M | $11.2M |
| 45 | Thrivewell Cancer Foundation San Antonio | $3.5M | $3.3M | $1.9M |
| 46 | Fort Bend Regional Council on Substance Abuse INC Stafford | $3.5M | $3.5M | $1.5M |
| 47 | Aids Interfaith Network INC Dallas | $2.9M | $2.9M | $1.8M |
| 48 | Faris Foundation Sugar Land | $2.9M | $1.8M | $5.7M |
| 49 | 3 Lefties Family Foundation San Antonio | $2.8M | $0 | $1.5M |
| 50 | Deaf Action Center Dallas | $2.8M | $2.8M | $4.6M |