| 1 | Devereux Foundation Villanova | $497.6M | $494.2M | $263.4M |
| 2 | Childrens Anesthesiology Associates Ltd Philadelphia | $109.2M | $105.5M | $95.8M |
| 3 | American Board of Internal Medicine Philadelphia | $105.8M | $105.8M | $224.3M |
| 4 | Aids Care Group Chester | $70.7M | $70.6M | $22.9M |
| 5 | American Association for Cancer Research Foundation Philadelphia | $53.4M | $52.9M | $4.8M |
| 6 | Ecog-acrin Medical Research Foundation INC Philadelphia | $53.3M | $53.3M | $16.0M |
| 7 | Concordia Community Support Services Cabot | $50.1M | $50.1M | $158.1M |
| 8 | The Wright Center for Graduate Medical Education Scranton | $49.1M | $47.9M | $37.5M |
| 9 | Butler Cancer Associates INC Pittsburgh | $29.0M | $29.0M | $9.2M |
| 10 | Allies for Health & Wellbeing Pittsburgh | $23.3M | $8.1M | $7.1M |
| 11 | United Disabilities Services Lancaster | $22.8M | $22.8M | $39.5M |
| 12 | The Heart Group of Lancaster General Health Lancaster | $18.8M | $18.8M | $3.9M |
| 13 | Michaels Way Fort Washington | $16.3M | $2.1M | $13.0M |
| 14 | Action Wellness Philadelphia | $16.1M | $15.8M | $6.6M |
| 15 | Vision Resources of Central Pennsylvania Harrisburg | $15.5M | $2.3M | $21.0M |
| 16 | Transplant Foundation Philadelphia | $13.9M | $4.5M | $70.8M |
| 17 | Malaria Consortium US INC Hermitage | $12.6M | $12.6M | $10.8M |
| 18 | Community Living and Support Services INC Pittsburgh | $12.2M | $11.7M | $14.4M |
| 19 | Eagles Autism Challenge INC Philadelphia | $12.1M | $11.1M | $10.2M |
| 20 | Dementia Society INC Doylestown | $10.8M | $2.0M | $7.7M |
| 21 | Accessabilities INC Butler | $10.1M | $10.0M | $8.1M |
| 22 | Breathe Pennsylvania Cranberry Twp | $9.4M | $1.1M | $35.5M |
| 23 | Upmc-st Clair Hospital Cancer Center Pittsburgh | $9.3M | $9.2M | $6.6M |
| 24 | Service Coordination Unlimited INC Erie | $9.2M | $9.2M | $5.6M |
| 25 | Alleghenies Unlimited Care Providers Johnstown | $9.0M | $9.0M | $17.5M |
| 26 | Davos Alzheimers Collaborative INC Wayne | $9.0M | $9.0M | $13.4M |
| 27 | Oncology Nursing Foundation Pittsburgh | $8.0M | $2.7M | $20.5M |
| 28 | Alder Health Services INC Harrisburg | $7.6M | $2.0M | $3.1M |
| 29 | Avenues Pottsville | $7.0M | $7.0M | $5.7M |
| 30 | Unite for Her Malvern | $7.0M | $5.9M | $5.0M |
| 31 | Deaf-hearing Communication Center INC Swarthmore | $6.8M | $6.6M | $4.3M |
| 32 | The Abim Foundation Philadelphia | $6.8M | $6.8M | $91.9M |
| 33 | Vista Adult Services Organization Hershey | $6.4M | $6.4M | $1.6M |
| 34 | Gbs Cidp Foundation International Conshohocken | $6.3M | $5.0M | $16.7M |
| 35 | Hepatitis B Foundation Doylestown | $6.2M | $3.5M | $20.5M |
| 36 | Charcot-marie-tooth Association Glenolden | $6.1M | $5.8M | $9.5M |
| 37 | Bucks County Biotechnology Center INC Doylestown | $6.1M | $5.8M | $34.3M |
| 38 | Lions Eye Bank of Delaware Valley Philadelphia | $5.9M | $5.7M | $16.8M |
| 39 | Jake Gittlen Memorial Golf Tournament Mars | $5.7M | $3.2M | $8.1M |
| 40 | Lancaster Cleft Palate Clinic Lancaster | $5.2M | $5.2M | $11.2M |
| 41 | United Mitochondrial Disease Foundation INC Pittsburgh | $5.0M | $3.7M | $6.4M |
| 42 | Wyoming Valley Aids Council Wilkes Barre | $4.4M | $4.4M | $1.5M |
| 43 | Primary Care Services Meadville | $4.3M | $4.3M | $317K |
| 44 | Fayette Oncology Associates Pittsburgh | $4.3M | $4.3M | $4.5M |
| 45 | Better Outcomes Living Diversely INC Harrisburg | $3.9M | $3.9M | $574K |
| 46 | Keystone Independence Management Hermitage | $3.9M | $3.9M | $725K |
| 47 | Penncares Hanover | $3.8M | $2.3M | $7.0M |
| 48 | Cystic Fibrosis Research Fund Ardmore | $3.7M | $3.5M | $6.0M |
| 49 | Beyond Celiac Ambler | $3.4M | $3.3M | $5.4M |
| 50 | Bringing Hope Home INC Malvern | $3.2M | $2.7M | $975K |