| 1 | Alzheimers Disease and Related Disorders Association INC Chicago | $612.6M | $457.2M | $523.7M |
| 2 | American Academy of Pediatrics INC Itasca | $183.7M | $138.5M | $177.8M |
| 3 | American Lung Association Chicago | $141.9M | $107.7M | $225.7M |
| 4 | American Academy of Orthopedic Surgeons Rosemont | $96.4M | $53.6M | $192.5M |
| 5 | Muscular Dystrophy Association Chicago | $87.5M | $60.4M | $58.0M |
| 6 | Radiological Society of North America INC Oak Brook | $86.8M | $68.5M | $218.3M |
| 7 | American Academy of Dermatology INC Rosemont | $82.1M | $53.6M | $128.5M |
| 8 | American Academy of Dermatology Association INC Rosemont | $50.6M | $15.9M | $27.7M |
| 9 | Aids Foundation of Chicago Chicago | $40.6M | $40.0M | $19.8M |
| 10 | American Osteopathic Association Chicago | $39.3M | $35.5M | $94.5M |
| 11 | University of Western States Chicago | $37.5M | $30.9M | $87.8M |
| 12 | Chicago House and Social Service Agency Chicago | $22.8M | $22.7M | $12.9M |
| 13 | American Association of Neurosurgeons INC Rolling Meadows | $20.6M | $15.3M | $31.9M |
| 14 | American Society for Gastrointestinal Endoscopy Downers Grove | $19.4M | $17.3M | $42.0M |
| 15 | Congress of Neurological Surgeons INC University of Michigan Schaumburg | $18.1M | $18.0M | $37.8M |
| 16 | American Society for Surgery of the Hand Chicago | $16.9M | $12.7M | $42.5M |
| 17 | National Society to Prevent Blindness Chicago | $16.3M | $14.7M | $29.2M |
| 18 | Families of Sma Elk Grove Vlg | $16.2M | $15.2M | $10.6M |
| 19 | Plastic Surgery Foundation Arlington Heights | $16.0M | $3.7M | $23.1M |
| 20 | Caitlin Bull Foundation River Forest | $13.6M | $0 | $5.4M |
| 21 | Association of Bone & Joint Surgeons Schaumburg | $13.3M | $5.0M | $41.8M |
| 22 | American Orthopaedic Society for Sports Medicine Rosemont | $12.7M | $9.3M | $19.5M |
| 23 | Alliance Nctn Foundation Chicago | $10.9M | $10.9M | $4.5M |
| 24 | Alzheimers Impact Movement Chicago | $10.8M | $10.8M | $726K |
| 25 | American Epilepsy Society Chicago | $10.7M | $10.5M | $20.3M |
| 26 | Crosspoint Human Services Danville | $10.1M | $10.0M | $11.1M |
| 27 | American Academy of Dental Sleep Medicine Lisle | $9.7M | $4.9M | $17.1M |
| 28 | Pulmonary Fibrosis Foundation Chicago | $9.3M | $8.3M | $15.3M |
| 29 | The Association of the Jewish Blind of Chicago Chicago | $8.1M | $1.6M | $22.6M |
| 30 | American Orthopaedic Association Rosemont | $7.1M | $4.9M | $18.6M |
| 31 | Neurocritical Care Society INC Chicago | $6.7M | $4.8M | $5.5M |
| 32 | Midwest Asian Health Association - Maha Chicago | $6.0M | $6.0M | $7.8M |
| 33 | American Association of Neurological Surgeons INC Rolling Meadows | $5.7M | $5.7M | $31.6M |
| 34 | Pediatric Orthopaedic Society of North America Oakbrook Ter | $5.4M | $5.3M | $18.6M |
| 35 | American Academy of Pediatric Dentistry Foundation Chicago | $5.0M | $1.9M | $18.8M |
| 36 | The American Laryngological Rhinological and Otological Oak Brook | $5.0M | $3.0M | $24.1M |
| 37 | Wellness House Hinsdale | $4.8M | $4.6M | $5.1M |
| 38 | Arthroscopy Association of North America Education Foundation Rosemont | $4.5M | $1.3M | $18.6M |
| 39 | Society of Cardiovascular Anesthesiologists INC East Dundee | $4.2M | $4.2M | $10.9M |
| 40 | American Association for the Surgery of Trauma Chicago | $4.1M | $4.1M | $10.4M |
| 41 | Cancer Wellness Center Northbrook | $3.9M | $2.4M | $4.6M |
| 42 | R O W Foundation Naperville | $3.9M | $0 | $27K |
| 43 | Joint Review Committee on Education in Radiologic Technology Chicago | $3.9M | $3.3M | $4.3M |
| 44 | Sjl Health Systems INC Delavan | $3.7M | $3.7M | $1.8M |
| 45 | Danny Did Foundation Evanston | $3.6M | $1.7M | $3.2M |
| 46 | Illinois Telecommunications Access Corporation Springfield | $3.5M | $3.5M | $4.7M |
| 47 | American Academy of Periodontology Foundation Chicago | $3.4M | $1.4M | $8.5M |
| 48 | Health and Medicine Policy Research Group Chicago | $3.3M | $3.2M | $2.7M |
| 49 | Mission Msa Chicago | $3.3M | $1.8M | $5.0M |
| 50 | Eastern Association for the Surgery of Trauma Chicago | $3.2M | $2.6M | $7.6M |